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KMID : 0352819890050020001
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Kosin Medical Journal
1989 Volume.5 No. 2 p.1 ~ p.11
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Chromosome Aberration of Human Lymphocyte Infected with Ureaplasma urealyicum
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장명웅/Chang, myung Woong
김광혁/박인달/유경식/Kim, Kwang Hyuk/Park, In Dal/Yoo, Gyung Sig
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Abstract
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The Present study was made to observe the karyological and morphological changes of chromosome that occur to human lymphocyte infected with Ureaplasma urealyticum.
Karyotypes and morphological changes of chromosome were observed using short term blood culture and micro-method. The results of this study are :
1. Survival time of Ureaplasma urealyticum in the supernatant of human lymphocyte culture with RPMI 1640 was 2 days.
2. Ureaplasma urealyticum T-960(standard strain) and K-15(isolated from patient with cervicitis) strains caused mitotic inhibition of human lymphocyte when an inoculum of 105 color changing unit per ml of these microorganisms.
3. Ureaplasma urealyticum T-960 and K-15 were able to induced chromosome aberrations of human lymphocytes in statistically significant numbers. These chromosome aberration included tetraploid, chromatid gap, chromatid break, chromosome break, chromatid exchange, dicentric chromosome, acentric chromosome, endoreduplication, quardriradial exchange, multiple exchange, ring chromosome, and satellite chromosome.
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